Homeostatic Regulation – LDL Receptors

A recent news story

http://www.nytimes.com/2013/02/04/business/medicines-co-licenses-rights-to-cholesterol-drug.html?_r=0

covered the development of drugs targeting PCSK9, a “pro-protein” that decreases the density of LDL receptors (e.g. in the liver). The interesting part for the computational biologist is the regulation of LDL receptors: The density of LDL receptors depends on the amount of LDL available in the bloodstream. With more LDL, their density increases. Another way to increase LDLR density are statins (drugs). However, statins also activate PCSK9. And PCSK9 acts to decrease LDL. In other words, it looks as if we have a classic homeostatic regulation, and by interfering with it at one point, we may activate processes that counteract the wanted drug effect. If we add PCSK9 inhibitors now (by monoclonal antibodies, or as in this case by miRNA interference), we believe we may have a more radical effect on keeping LDLR active. In any case, it tells us that we need to understand a system that we interfere with.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s