A new paper Universal features of dendrites through centripetal branch ordering published: July 3, 2017) shows more or less the opposite of what it cites as common wisdom: „neuronal computation is known to depend on the morphology of dendrites”
Namely, since all dendrites follow general topological principles, it is probably not the dendritic morphology that matters in a functional sense. To make a dendrite functional, i.e. let it participate in adaptive information processing, we have to refer to the ion channels and GPCRs that populate the spines and shafts and shape the generation of action potentials.
Dendritic integration: 60 years of progress. (Stuart GJ, Spruston N.) Nat Neurosci. 2015 Dec;18(12):1713-21. doi: 10.1038/nn.4157. Epub 2015 Nov 25. Review. PMID:26605882.
Plasticity of dendritic function. Magee JC, Johnston D. Curr Opin Neurobiol. 2005 Jun;15(3):334-42. Review. PMID:15922583
Gabriele Scheler BMC Neurosci. 2013; 14(Suppl 1): P344. Published online 2013 Jul 8. doi: 10.1186/1471-2202-14-S1-P344. PMCID: PMC3704850
Neuromodulation of circuits with variable parameters: single neurons and small circuits reveal principles of state-dependent and robust neuromodulation. Marder E1, O’Leary T, Shruti S. Annu Rev Neurosci. 2014;37:329-46. doi: 10.1146/annurev-neuro-071013-013958.
balanced excitation inhibition
explaining attention by top-down and bottom-up processes
I should collect some more. Why are they bad? Because they are half-truths. There is “something” right about these ideas, but as scientific concepts, the way they are currently defined, I think they are wrong. Need to be replaced.
To understand neural coding, we have to regard the relationship of synchronized membrane potentials (local field potentials) and the firing of the individual neuron. We have two different processes here, because the firing of the single neuron is not determined simply by the membrane potential exceeding a fixed threshold. Rather, the membrane potential’s fluctuation does not predict the individual neuron’s firing, because the neuron has a dynamic, flexible firing threshold that is determined by its own internal parameters. Also, the membrane potential is subject to synchronization by direct contact between membranes, it is not necessarily or primarily driven by synaptic input or neuronal spiking. Similarly, HahnG2014(Kumar) have noted that membrane synchronization cannot be explained from a spiking neural network.
The determination of an individual neuron’s firing threshold is a highly dynamic process, i.e. the neuron constantly changes its conditions for firing without necessarily disrupting its participation in ongoing membrane synchronization processes. In other words, membrane potential fluctuations are determined by synaptic input as well as local synchronization processes, and spikes depend on membrane potentials filtered by a dynamic, individually adjustable firing threshold.
The model for a neural coding device contains the following:
A neuronal membrane that is driven by synaptic input and synchronized by local interaction (both excitatory and inhibitory)
A spiking threshold with internal dynamics, possibly within an individual range, which determines spiking from membrane potential fluctuations.
In this model the neural code is determined by at least three factors: synaptic input, local synchronization, and firing threshold value. We may assume that local synchronization acts as a filter for signal loss, i.e. it unifies and diminishes differences in synaptic input. Firing thresholds act towards individualization, adding information from stored memory. The whole set-up acts to filter the synaptic input pattern towards a more predictable output pattern.